ChemicalBook > CAS DataBase List > 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

Product Name
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
CAS No.
1009298-59-2
Chemical Name
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
Synonyms
CS-486;AZD2014;AZD2014, >=98%;AZD 2014; AZD-2014;AZD2014(Vistusertib);Vistusertib (AZD2014);Osimertinib Impurity 4;AZD2014;AZD 2014; AZD-2014;Vistusertib, 98%, a novel mTOR inhibitor;3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide
CBNumber
CB02604239
Molecular Formula
C25H30N6O3
Formula Weight
462.54
MOL File
1009298-59-2.mol
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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Property

Melting point:
233-237oC
Density 
1.231
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
14.45±0.46(Predicted)
form 
Solid
color 
Light Yellow
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17378
Product name
AZD 2014
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17378
Product name
AZD 2014
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17378
Product name
AZD 2014
Purity
≥98%
Packaging
10mg
Price
$146
Updated
2024/03/01
Cayman Chemical
Product number
17378
Product name
AZD 2014
Purity
≥98%
Packaging
25mg
Price
$305
Updated
2024/03/01
TRC
Product number
A808115
Product name
AZD2014
Packaging
200mg
Price
$890
Updated
2021/12/16
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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Chemical Properties,Usage,Production

Uses

AZD2014 is a dual mTORC1 and mTORC2 inhibitor. Studies show that AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines.

Biological Activity

azd2014 is a novel, potent and highly selective dual inhibitor of the mammalian rapamycin (mtorc1 and mtorc2) with an ic50 value of 2.8 nm. it is an oral inhibitor and possesses potential antineoplastic activity.azd2014 enhanced susceptibility of glioblastoma stem-like cells (gscs) to irradiation both in vitro and under orthotopic in vivo conditions. kahn j et al pretreated cd133+ and cd15+ gsc cells with azd2014 (2 μm) for 1 hour, followed by irradiation. the effect was then measured by clonogenic survival analysis [2]. using in vitro screening, they demonstrated that the combination of ibrutinib, an inhibitor of the tyrosine kinase btk, and azd2014 could dramatically induce apoptosis in abc-subtype dlbcl cell lines. thereby, the combination of azd2014 with a btk inhibitor is a promising therapeutic method to cure patients with abc-type dlbcl [3]. in hepatocellular carcinoma cells, azd2014 gave rise to a more complete inhibition of mtorc1 than rapamycin, while the inhibition of mtorc2 prevented the feedback activation of akt signaling. therefore, azd2014 was identified to be more efficacious in the induction of apoptosis, autophagy, and cell cycle arrest, resulting in a significant proliferation suppression of the cells, in contrast with rapamycin [4].in a recent human pharmacokinetic and pharmacodynamic study, a dose of 50mg bd(twice a day)azd2014 was recommended to achieve pharmacologically relevant plasma concentrations [5].

target

mTOR

References

optimization of potent and selective dual mtorc1 and mtorc2 inhibitors: the discovery of azd8055 and azd2014. bioorg med chem lett. 2013 mar 1;23(5):1212-6. the mtorc1/mtorc2 inhibitor azd2014 enhances the radiosensitivity of glioblastoma stem-like cells. neuro oncol. 2014 jan;16(1):29-37. synergistic induction of apoptosis by combination of btk and dual mtorc1/2 inhibitors in diffuse large b cell lymphoma. oncotarget. 2014 jul 15;5(13):4990-5001.dramatic antitumor effects of the dual mtorc1 and mtorc2 inhibitor azd2014 in hepatocellular carcinoma. am j cancer res. 2014 dec 15;5(1):125-39. ecollection 2015.first-in-human pharmacokinetic and pharmacodynamic study of the dual m-torc 1/2 inhibitor, azd2014. clin cancer res. 2015 mar 24. pii: clincanres.2422.2014.

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
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View Lastest Price from 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide manufacturers

Career Henan Chemical Co
Product
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 1009298-59-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1009298-59-2, 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamideRelated Search:


  • 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
  • AZD2014
  • 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide
  • 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide AZD2014
  • AZD2014 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
  • 3-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-N-methylbenzamide
  • AZD2014, >=98%
  • AZD2014(Vistusertib)
  • AZD2014;AZD 2014; AZD-2014
  • Vistusertib, 98%, a novel mTOR inhibitor
  • Vistusertib (AZD2014)
  • CS-486
  • AZD 2014; AZD-2014
  • Osimertinib Impurity 4
  • Benzamide, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl-
  • 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide USP/EP/BP
  • inhibit,Vistusertib,Apoptosis,Mammalian target of Rapamycin,AZD 2014,mTOR,Autophagy,Inhibitor,AZD-2014
  • 1009298-59-2
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • PI3K/Akt/mTOR